Which setting helps ensure optimal performance when dealing with large Excel files?

Selecting the setting to keep all versions during deduplication is essential when managing large Excel files. This ensures that no vital data or previous versions are inadvertently removed, which can occur during the deduplication process. When dealing with large datasets, it is crucial to preserve the integrity and completeness of the data. Keeping all versions allows users to maintain a comprehensive view of the data, which can be vital for audits, compliance, or simply for reference.

In contrast, while other settings may have their specific roles, they do not directly impact the management of large Excel files in the same way. For example, creating a source folder structure, using indexed search methods, or adjusting the time zone settings serves different purposes that might enhance usability or accessibility, but they are not as pivotal as preserving complete data integrity by choosing the deduplication method to keep all.